Ocean Outdoor, which runs the sites, will also turn off 19 screens across the two London Westfield shopping centres.
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Mackay succeeds Denise Turner, who is joining the IPA as media research director.
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A deal was signed in 2016, with the companies relaunching the site the following year.
OOH revenue in the UK grew 7.7% year on year to reach £1.4bn.
Work will run on The Standard, Outernet, OOH and social.
The media owner will install 1,000 screens and introduce new creative and motion capabilities.